Comparison of Left Ventricular End-Diastolic Volume
Approximated from Mean Blood Pressure and Stroke Volume
and End-Diastolic Volume Calculated from Left
Ventricular-Aortic Coupling
Takahiro Shiraishi,
Department of Anesthesiology and Reanimatology, University of Fukui Hospital, Fukui 910-1193, Japan;
Abstract: Objectives: The purpose of this study was to compare left ventricular end-diastolic volume
(EDV), derived from left ventricular arterial coupling (Ees/Ea), and mean arterial blood pressure.
Both of these methods of measuring EDV require some invasive procedure. However, the method
of measuring EDV approximate is less invasive than the EDV coupling measuring method. This
is because EDV approximate only requires arterial pressure waveform as an invasive procedure.
Methods: This study included 14 patients with normal cardiac function who underwent general
anesthesia. The point when blood pressure stabilized after the induction of anesthesia was taken as
a baseline according to the study protocol. At the point when systolic arterial blood pressure fell
10% or more from the baseline blood pressure, 300 mL of colloid solution was administered over
15 min. EDV approximate and EDV coupling were calculated for each of the 14 patients at three
points during the course of anesthetic. Each value was obtained by calculating a 5 min average. The
timing of these three points was 5 min before, 5 min during, and 5 min after infusion loading. Results:
The total number of comparable points was 42; 3 points were taken from each of the 14 participants.
Both EDV approximate and EDV coupling increased through the infusion load testing. Scatter plots
were prepared, and regression lines were calculated from the obtained values. A high correlation was
shown between EDV approximate and EDV coupling (R2 = 0.96, p < 0.05).
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